Eczema, also known as atopic dermatitis, affects millions worldwide, causing itchy, dry, inflamed skin that can disrupt daily life. While there’s no cure, effective creams can soothe symptoms, repair the skin barrier, and prevent flare-ups. Based on dermatologist recommendations, expert testing, and user reviews from 2025, the best creams focus on hydrating ingredients like ceramides, colloidal oatmeal, and shea butter, while avoiding irritants such as fragrances. These over-the-counter options are ideal for mild to moderate eczema; consult a dermatologist for severe cases or prescription needs.

Here are the top 5 eczema creams for 2025, ranked by efficacy, accessibility, and overall value.

1. La Roche-Posay Eczema Cream

4.7 out of 5 ratings

This fragrance-free cream is a dermatologist favorite for its ability to restore the skin’s microbiome and provide long-lasting hydration. It’s clinically proven to relieve itchiness and dryness, making it suitable for all ages, including babies.

Key Ingredients: Prebiotic thermal water, shea butter, niacinamide, glycerin.
Best For: Daily use on body and face during flare-ups.
Pros: Absorbs quickly without greasiness; accepted by the National Eczema Association; reduces redness in 1-2 weeks.
Cons: Slightly higher price point (around $20 for 6.76 oz).
Why It Stands Out: Testers with sensitive skin reported significant relief from persistent dryness, and it’s widely available at drugstores.

2. CeraVe 1% Hydrocortisone Anti-Itch Cream

4.6 out of 5 ratings

CeraVe 1% Hydrocortisone Anti-Itch Cream, Fragrance-Free Relief for Eczema-Prone & Dry Skin, 1 Ounce

A multi-tasking powerhouse, this ointment locks in moisture with a thick, occlusive formula that’s perfect for overnight use or severe dryness. It’s non-comedogenic and hypoallergenic, earning the National Eczema Association Seal of Acceptance.

Key Ingredients: Three essential ceramides, hyaluronic acid, petrolatum.
Best For: Barrier repair on hands, elbows, or cracked areas.
Pros: Affordable (about $15 for 12 oz); versatile for chapped lips or minor cuts; provides 24-hour hydration.
Cons: Thick texture may feel heavy during the day.
Why It Stands Out: Dermatologists praise its ceramide content for rebuilding the skin barrier, with users noting faster healing of eczema patches compared to regular lotions.

3. Aveeno Eczema Therapy Moisturizing Cream

4.7 out of 5 ratings

Powered by natural colloidal oatmeal, this cream soothes irritation and protects against environmental triggers. It’s steroid-free and pediatrician-recommended, ideal for families dealing with eczema.

Key Ingredients: Colloidal oatmeal, ceramides, feverfew.
Best For: Itchy, inflamed skin on the body.
Pros: Gentle for daily application; fragrance-free; budget-friendly (around $10 for 7.3 oz).
Cons: May require reapplication for very dry skin.
Why It Stands Out: In 2025 testing, it excelled at calming flare-ups without residue, and experts highlight its anti-inflammatory properties for long-term management.

4. Vanicream Moisturizing Cream

4.7 out of 5 ratings

This minimalist formula is free of dyes, parabens, and fragrances, making it a go-to for ultra-sensitive skin. It provides deep hydration without stinging, even on broken skin.

Key Ingredients: Petrolatum, ceramides, hyaluronic acid.
Best For: Sensitive or allergy-prone eczema.
Pros: Non-greasy absorption; large tub size (16 oz for $13); dermatologist-endorsed for all skin types.
Cons: Lacks additional soothing agents like oatmeal.
Why It Stands Out: Reviewers with chronic eczema reported reduced itching within days, and it’s frequently recommended by the National Eczema Association for its purity.

5. Eucerin Eczema Relief Cream

4.7 out of 5 ratings

Designed specifically for eczema, this cream offers a cooling sensation upon application while repairing the skin barrier. It’s suitable for face and body and helps prevent flares with consistent use.

Key Ingredients: Colloidal oatmeal, ceramides, licorice extract.
Best For: Cooling relief during active itchiness.
Pros: Fragrance-free; provides instant calm; affordable (about $12 for 8 oz).
Cons: Jar packaging may be less hygienic for on-the-go use.
Why It Stands Out: 2025 expert reviews note its effectiveness in reducing sleep disturbances from itching, with testers appreciating the non-irritating formula for daily routines.

Tips for Choosing and Using Eczema Creams

• Application: Apply twice daily, especially after bathing while skin is damp, to seal in moisture. Use the “soak and smear” method for best results.
• Ingredients to Seek: Opt for ceramides, humectants (like glycerin), and emollients (like petrolatum) to hydrate and protect. Avoid alcohol, fragrances, and dyes.
• When to See a Doctor: If OTC creams don’t improve symptoms in 1-2 weeks or if infection signs appear, seek professional advice. Combine with gentle cleansers and avoid hot showers.
• General Advice: Patch-test new products and maintain a consistent routine. For infants, stick to baby-specific formulas like those from Aveeno or CeraVe.

These creams can transform eczema management, but individual results vary. Always prioritize products with the National Eczema Association Seal for proven safety and efficacy.