5 Best Mouthwashes of 2025

Maintaining optimal oral health goes beyond brushing and flossing—mouthwash serves as a crucial final step to kill lingering bacteria, freshen breath, and protect against cavities and gum issues. In 2025, with advancements in alcohol-free formulas and natural ingredients, the options are better than ever. To compile this list, we reviewed dentist recommendations and expert-tested picks from trusted sources like The Strategist, NBC Select, Health.com, and CNN Underscored. Our selections prioritize ADA-approved products with proven efficacy, covering common needs like cavity prevention, bad breath, and gum health. Prices are approximate based on major retailers and may vary.

1. ACT Anticavity Fluoride Rinse – Best Overall

ACT stands out as the top all-around choice for everyday use, thanks to its affordability, accessibility, and enamel-strengthening power. Dentists rave about it for preventing cavities in high-risk individuals while providing a clean, fresh feel without drying out the mouth.

• Key Ingredients: Sodium fluoride (0.05%), xylitol, sodium bicarbonate.
• Pros: ADA-approved; strong yet non-stinging mint flavor; budget-friendly ($4–$6 for 18 oz); elevates mouth pH for better protection.
• Cons: Wait 30 minutes after use before eating/drinking to maximize fluoride benefits.
• Best For: General cavity prevention and daily maintenance.

2. TheraBreath Fresh Breath Oral Rinse – Best for Bad Breath

If halitosis is your main concern, TheraBreath neutralizes odor-causing sulfur compounds for up to 24 hours of fresh breath. Founded by a dentist, it’s a go-to for those seeking a gentle, effective formula that doesn’t disrupt your oral microbiome. 0 1 13 14

• Key Ingredients: Sodium chlorite (oxygenating agent), xylitol, peppermint oil.
• Pros: Alcohol-free and vegan; mild flavor without burn; combats plaque and gingivitis too; ADA-accepted.
• Cons: Not optimized for severe dry mouth relief.
• Best For: Long-lasting breath freshening and mild gum support.
• Price: $10–$16 for 16 oz.

3. Colgate Total Active Prevention Mouthwash – Best for Gingivitis

Colgate Total excels at fighting plaque and gingivitis by targeting bacteria for up to 24 hours, making it ideal for those with early gum inflammation. Its alcohol-free design ensures comfort during twice-daily use.

• Key Ingredients: Cetylpyridinium chloride (antibacterial), zinc (breath freshener).
• Pros: Leaves teeth feeling ultra-clean; strong peppermint erases food odors; widely available and affordable ($5–$8 for 32 oz).
• Cons: Intense flavor might overwhelm sensitive users.
• Best For: Plaque reduction and gum health prevention.
• Price: $5–$8 for 32 oz.

4. Listerine Total Care Zero Alcohol Anticavity Mouthwash – Best for Plaque Control

Listerine’s essential oil blend delivers clinical-strength plaque reduction and cavity protection without the burn of alcohol. It’s a solid pick for comprehensive germ-killing in a mild package.

• Key Ingredients: Fluoride, eucalyptol, menthol, thymol (essential oils).
• Pros: ADA-approved; freshens breath while strengthening enamel; gentle enough for daily routines ($6–$9 for 32 oz).
• Cons: Milder taste may not satisfy those who prefer bold flavors; 30-minute post-rinse wait required.
• Best For: All-in-one plaque, cavity, and breath protection.
• Price: $6–$9 for 32 oz.

5. Biotène Dry Mouth Oral Rinse – Best for Dry Mouth Relief

For those battling xerostomia from medications or conditions like Sjögren’s, Biotène provides lasting moisture and cavity prevention without irritation. It’s safe for frequent use and supports overall comfort.

• Key Ingredients: Glycerin, xylitol (moisturizers and cavity fighters).
• Pros: Up to 4 hours of relief; alcohol- and sugar-free; pH-balanced for sensitive mouths ($8–$12 for 33 oz).
• Cons: No built-in measuring cap; less focused on whitening or intense freshening.
• Best For: Hydration and gentle daily care for dry mouth sufferers.
• Price: $8–$12 for 33 oz.

Final Thoughts

Incorporating one of these mouthwashes into your routine can elevate your oral hygiene, but remember: they’re supplements, not substitutes, for brushing, flossing, and professional checkups. Consult your dentist to match the right formula to your specific needs, especially if you have sensitivities or conditions. With these picks, achieving a healthier, fresher smile is easier than ever.